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MHC-Peptide-Ankyrons
MHC-Peptide Specific Ankyrons™
a breakthrough for targeting MHC-peptide complexes
A clear solution to a long-standing problem
Detecting and targeting specific MHC-peptide complexes is of material interest for understanding many disease conditions better and for developing novel therapeutic interventions. It has been very challenging to develop antibodies that bind selectively to an MHC-peptide combination over a more general MHC allotype.
Ankyrons provide a clear and powerful solution to this problem. Selected directly in vitro from our Teralibrary we can already offer a growing range of more than 16 of the most popular MHC-peptide combinations in cancer and infectious diseases in the listing below. Using guided selection we are able to select sequence specific Ankyrons quickly. ProImmune is also the world leader by publications from a commercial source in MHC-peptide multimer technology. So building MHC-peptide antigens for new Ankron discovery is already our core business.
Contact us with your Custom Ankyron™ requirements or Request a Quote for us to make a quantum leap in your MHC-peptide targeting project.
Data for MHC-peptide specific Ankyron staining
Figure. Staining of cell line constitutively expressing an infectious disease-specific MHC-peptide complex combination with Ankyrons selected to specifically bind the same (MHC-peptide specificity and study background are still subject to publication). Unstained data show background fluorescence. The cell line was stained with MHC-peptide specific Ankyrons as well as Ankyrons specific to an irrelevant peptide in the context of the same MHC allele. Staining was carried out in each case with and without additional stimulation with IFNγ. Stimulation with IFNγ strongly upregulates MHC-peptide presentation. In stimulated cells the staining of the cell line with the specific Ankyron separates clearly from that of the non specific Ankyron staining. Data provided by Prof. Antonio Bertoletti’s group at Duke NUS, Singapore.
List of available MHC-peptide specific Ankyrons
| ANK_ID | Target Name (UniprotID) | Protein Name | Keywords | CloneID (Signal:Noise) | Applications | |||
|---|---|---|---|---|---|---|---|---|
| ANK04018 | HLA_DRB10401 SLQPLALEGSLQKRG | Ankyron anti-DRA1*01:01/DRB1*03:01 SLQPLALEGSLQKRG [Insulin Precursor 76-90] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40661 (34) CL40664 (33) CL40658 (24) CL40663 (22) CL40660 (21) CL40665 (16) | ||||
| ANK04017 | HLA_DRB10401 PYYVVDLSVRGM | Ankyron anti-DRA1*01:01/DRB1*04:01 PYYVVDLSVRGM [BHRF1 122-133] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40655 (1487) CL40657 (671) CL40654 (58) CL40656 (19) | ||||
| ANK03350 | HLA_DRB10401 PVSKMRMATPLLMQA | Ankyron anti-DRA1*01:01/DRB1*04:01 PVSKMRMATPLLMQA antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | DR4PVD5 | ||||
| ANK04016 | HLA_DRB10401 IAFTSEHSHFSLK | Ankyron anti-DRA1*01:01/DRB1*04:01 IAFTSEHSHFSLK [GAD65 274-286] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40633 (5900) CL40635 (5478) CL40631 (1530) CL40647 (572) CL40640 (428) CL40646 (409) | ||||
| ANK04015 | HLA_DRB10401 GAGSLQPLALEGSLQKRG | Ankyron anti-DRA1*01:01/DRB1*04:01 GAGSLQPLALEGSLQKRG antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40622 (108) CL40627 (108) CL40625 (74) CL40628 (60) CL40624 (54) CL40616 (54) | ||||
| ANK04014 | HLA_DRB10301 CTFEYVSQPFLMDLE | Ankyron anti-DRA1*01:01/DRB1*03:01 CTFEYVSQPFLMDLE [SARS-CoV2 Spike Protein (S) 166-180] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40613 (70) CL40611 (63) CL40612 (52) | ||||
| ANK03608 | HLA_B0801 FLRGRAYGL | Ankyron anti-B*08:01 FLRGRAYGL [EBV EBNA-3A 193-201] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CH30755 (737) CH30756 (57) | ||||
| ANK03606 | HLA_B0702 RPPIFIRRL | Ankyron anti-B*07:02 RPPIFIRRL [EBV EBNA-3A 247-255] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30687 (4161) CD30689 (3404) CD30693 (2966) CD30686 (1888) CD30692 (1811) CD30688 (985) | ||||
| ANK03605 | HLA_B0702 RPHERNGFTVL | Ankyron anti-B*07:02 RPHERNGFTVL [HCMV pp65 265-275] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BI40242 (6596) BI40246 (1096) | ||||
| ANK03510 | HLA_A2402 EYLVSFGVW | Ankyron anti-A*24:02 EYLVSFGVW [HBV core 117-125] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40735 (42459) AO40736 (19815) AO40737 (19802) AO40738 (17300) AO40739 (16475) AO40740 (16370) | ||||
| ANK03601 | HLA_A1101 SSCSSCPLSK | Ankyron anti-A*11:01 SSCSSCPLSK [EBV LMP-2 340-349] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30727 (5178) CD30723 (3282) CD30724 (2379) CD30726 (1534) CD30725 (149) | ||||
| ANK03599 | HLA_A1101 IVTDFSVIK | Ankyron anti-A*11:01 IVTDFSVIK [EBV EBNA-4 416-424] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30770 (2737) CD30766 (1123) CD30758 (772) CD30769 (599) CD30754 (484) CD30753 (406) | ||||
| ANK03598 | HLA_A0301 KTFPPTEPK | Ankyron anti-A*11:01 KTFPPTEPK [SARS-CoV-2 Nucleocapsid protein 362-370 (confirmed epitope)] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S30110 (76) 01S30109 (15) | ||||
| ANK03841 | HLA_A0301 KILPEVKEK | Ankyron anti- A*02:01 KILPEVKEK antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S30108 (13) 01S30107 (6) 01S30106 (5) | ||||
| ANK03509 | HLA_A0201 YMDGTMSQV | Ankyron anti-A*02:01 YMDGTMSQV [Tyrosinase 369-377 (371D)] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40342 (4825) | ||||
| ANK03508 | HLA_A0201 YLSGANLNL | Ankyron anti-A*02:01 YLSGANLNL [Carcinogenic Embryonic Antigen (CEA) 571-579] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40318 (31346) BC40319 (13353) BC40320 (4422) BC40321 (2505) BC40322 (2306) BC40323 (1243) | ||||
| ANK03597 | HLA_A0201 YLQPRTFLL | Ankyron anti-A*02:01 YLQPRTFLL [SARS-Cov-2 Spike glycoprotein 269-277 (confirmed epitope)] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30729 (20508) CD30731 (12016) CD30737 (11410) CD30742 (11360) CD30730 (10022) CD30732 (9033) | ||||
| ANK03596 | HLA_A0201 WLSLLVPFV | Ankyron anti-A*02:01 WLSLLVPFV [HBV surface antigen 172-181] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40604 (57) 01S30105 (7) | ||||
| ANK03327 | HLA_A0201 SLLQHLIGL | Ankyron anti-A*02:01 SLLQHLIGL [PRAME 425-433] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S20154 (42) 01S20153 (15) | ||||
| ANK04042 | HLA_A0201 SLLMWITQC | Ankyron anti-A*02:01 SLLMWITQC [NY-ESO-1 157-165 (9C)] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S20151 (680) 01S20152 (63) | ||||
| ANK03593 | HLA_A0201 SLLFLLFSL | Ankyron anti-A*02:01 SLLFLLFSL [20-28] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S30104 (1192) BI40167 (37) BI40168 (34) BI40169 (31) BI40170 (31) BI40172 (25) | ||||
| ANK03506 | HLA_A0201 SIVSPFIPLL | Ankyron anti- A*02:01 SIVSPFIPLL antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40949 (8070) AO40950 (6678) AO40951 (6631) AO40952 (6243) AO40953 (6162) AO40954 (5880) | ||||
| ANK03326 | HLA_A0201 NLVPMVATV | Ankyron anti-A*02:01 NLVPMVATV [HCMV pp65 495-504] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S20150 (27) | ||||
| ANK03505 | HLA_A0201 LMLGEFLKL | Ankyron anti-A*02:01 LMLGEFLKL [Survivin 96-104] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40451 (6994) BC40452 (6343) BC40453 (283) | ||||
| ANK03504 | HLA_A0201 KTWGQYWQV | Ankyron anti-A*02:01 KTWGQYWQV [gp100 (pmel17) 154-162] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40538 (10637) BC40539 (5471) BC40540 (4172) BC40541 (3977) BC40542 (3773) BC40543 (2792) | ||||
| ANK03331 | HLA_A0201 KLVALGINAV | Ankyron anti-A*02:01 KLVALGINAV [HCV NS3 1406-1415] antibody replacement | Human, MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S40224 (2154) 01S40226 (1559) 01S40225 (1400) 01S40227 (918) 01S40228 (578) 01S40229 (361) | ||||
| ANK03589 | HLA_A0201 KLSGLGINAV | Ankyron anti-A*02:01 KLSGLGINAV [HCV NS3 1406-1415] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BI40209 (167) BI40212 (38) BI40214 (22) BI40215 (20) BI40217 (16) BI40218 (16) | ||||
| ANK04026 | HLA_A0201 KLSDRGVKI | Ankyron anti-A*02:01 KLSDRGVKI antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30787 (3200) CD30773 (346) CD30786 (91) CD30789 (38) CD30788 (17) | ||||
| ANK04012 | HLA_A0201 KLNSSVYSL | Ankyron anti- A*02:01 KLNSSVYSL antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CL40610 (68) | ||||
| ANK03503 | HLA_A0201 KIFGSLAFL | Ankyron anti-A*02:01 KIFGSLAFL [HER-2/neu 369-377] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40454 (1723) | ||||
| ANK03586 | HLA_A0201 ILKEPVHGV | Ankyron anti-A*02:01 ILKEPVHGV [HIV-1 RT 476-484] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BI40151 (20) | ||||
| ANK03502 | HLA_A0201 ILAKFLHWL | Ankyron anti-A*02:01 ILAKFLHWL [Telomerase 540-548] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40487 (5737) BC40488 (601) BC40490 (29) BC40489 (29) BC40491 (11) | ||||
| ANK03584 | HLA_A0201 GLSRYVARL | Ankyron anti-A*02:01 GLSRYVARL antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S30101 (932) | ||||
| ANK03500 | HLA_A0201 GLSPTVWLSV | Ankyron anti-A*02:01 GLSPTVWLSV [HBV surface antigen 185-194] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40809 (17393) AO40810 (15500) AO40811 (12288) AO40812 (11264) AO40813 (10276) AO40814 (8852) | ||||
| ANK03499 | HLA_A0201 GLPRYVARL | Ankyron anti- A*02:01 GLPRYVARL antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40482 (24819) AO40483 (12246) AO40484 (8825) AO40485 (8013) AO40486 (6373) AO40487 (5265) | ||||
| ANK03330 | HLA_A0201 GLCTLVAML | Ankyron anti-A*02:01 GLCTLVAML [EBV BMLF-1 259-267] antibody replacement | Human, MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S40167 (192) 01S40165 (327) 01S40167 (192) 01S40169 (123) 01S40173 (65) 01S40168 (54) | ||||
| ANK04041 | HLA_A0201 GILGFVFTL | Ankyron anti-A*02:01 GILGFVFTL [Influenza A MP 58-66] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S20149 (53) | ||||
| ANK04025 | HLA_A0201 FMKAVCVEV | Ankyron anti- A*02:01 FMKAVCVEV antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30812 (250) CD30813 (59) | ||||
| ANK03498 | HLA_A0201 FLWGPRALV | Ankyron anti-A*02:01 FLWGPRALV [MAGEA3 271-279] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BC40585 (61) BC40586 (44) BC40587 (13) | ||||
| ANK03496_1 | HLA_A0201 FLPSDFFPSV | Qualified Ankyron anti-A*02:01 FLPSDFFPSV [HBV core antigen 18-27] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | APS40107 (48) | A*02:01 FLPSDFFPSV [HBV core antigen 18-27] - (APS4010)
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| ANK03496 | HLA_A0201 FLPSDFFPSV | Ankyron anti-A*02:01 FLPSDFFPSV [HBV core antigen 18-27] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AP40658 (9482) AO40857 (8105) AO40858 (3535) AO40859 (3083) AO40860 (2698) AO40861 (2611) | ||||
| ANK03341_1 | HLA_A0201 FLLTRILTI | Qualified Ankyron anti-A*02:01 FLLTRILTI [HBV envelope 183-191] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40418 (5085) | A*02:01 FLLTRILTI [HBV envelope 183-191] - (AO40418)
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| ANK03341_2 | HLA_A0201 FLLTRILTI | Qualified Ankyron anti-A*02:01 FLLTRILTI [HBV envelope 183-191] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40422 (4290) | A*02:01 FLLTRILTI [HBV envelope 183-191] - (AO40422)
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| ANK03341 | HLA_A0201 FLLTRILTI | Ankyron anti-A*02:01 FLLTRILTI [HBV envelope 183-191] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | AO40406 (57191) AO40407 (27080) AO40408 (19167) AO40410 (16958) AO40413 (10979) AO40414 (10545) | ||||
| ANK03329 | HLA_A0201 FLLSLGIHL | Ankyron anti-A*02:01 FLLSLGIHL [HBV polymerase 573-581] antibody replacement | Human, MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S40132 (1016) 01S40139 (858) 01S40133 (353) 01S40131 (335) 01S40144 (308) 01S40137 (277) | ||||
| ANK04040 | HLA_A0201 ELAGIGILTV | Ankyron anti-A*02:01 ELAGIGILTV [MelanA / MART 26-35] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S20148 (7) | ||||
| ANK03581 | HLA_A0201 CINGVCWTV | Ankyron anti-A*02:01 CINGVCWTV [HCV NS3 1073-1081] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BI40253 (101000) BI40254 (21763) BI40255 (1181) | ||||
| ANK03578 | HLA_A0101 TTDPSFLGRY | Ankyron anti-A*01:01 TTDPSFLGRY [SARS-CoV-2 Replicase polyprotein 1ab 1637-1646 (confirmed epitope)] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30695 (2379600) CD30704 (37096) CD30708 (16462) CD30713 (15272) CD30709 (14025) CD30710 (13543) | ||||
| ANK03577 | HLA_A0101 FTSDYYQLY | Ankyron anti-A*01:01 FTSDYYQLY [SARS-CoV-2 ORF3a 207-215 (confirmed epitope)] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BI40251 (436) BI40252 (236) | ||||
| ANK03576 | HLA_A0101 EVDPIGHLY | Ankyron anti-A*01:01 EVDPIGHLY [MAGE-A3 168-176] antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | BI40191 (522) BI40192 (249) BI40195 (27) BI40201 (21) BI40204 (19) BI40205 (18) | ||||
| ANK04024 | H2Kb_SIINFEKL | Ankyron anti-H2Kb_SIINFEKL antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | CD30779 (295) CD30780 (278) CD30784 (237) CD30777 (228) CD30778 (192) CD30782 (139) | ||||
| ANK03343 | H2Kb_KSPWFTTL | Ankyron anti-MuLV env 622-629 (MC38) antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S40104 (1696) 01S40105 (1500) 01S40101 (1326) 01S40103 (1244) 01S40107 (1168) 01S40106 (637) | ||||
| ANK04039 | H2Kb | Ankyron anti-H2Kb antibody replacement | MHC, p-MHC, HLA, MHC-peptide complex, pMHC, peptide-MHC | 01S20147 (1072) |
